Strain Data Sheet
Data update: Jul 19, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC02097  
Type Targeted MutationCartagena   wks
Species Mus musculus  
Strain name STOCK Izumo1<tm1Osb>  
Former Common name Izumo KO  
H-2 Haplotype No Data  
Background strain No Data  
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Drs. Naokazu Inoue and Masaru Okabe at Osaka University in 2003. 129, C57BL/6 and DBA/2 mixed background.  
Strain description Izumo1 is a immunoglobulin super family protein that is required for sperm to fuse with eggs. Homozygous mutant mice are viable but males are sterile. The Izumo-deficient sperm can bind to an egg, and even burrow through the zona pellucida, but are incapable of fusing with egg.  
Colony maintenance Sibling Mating (Hemizygote x Wild-type, Hemizygote)
Homozygous mutant males are sterile.  
Health Report
BRC facility Health Report in the last year and a half

Examination Date Room Rack
Mar 9, 2009 2-検 D
Jan 13, 2009 2-検 D
Nov 10, 2008 2-検 D
Sep 8, 2008 2-検 D
Jul 7, 2008 2-検 D
May 13, 2008 2-検 D
May 12, 2008 2-検 D
Mar 3, 2008 2-検 D
Gene Details
Promoter No Data  
 1 Symbol Izumo1  
Symbol name izumo sperm-egg fusion 1  
Chromosome 7  
Common name 1700058F15Rik  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 7  
Common name neo; neomycin;  
Symbol description No Data  
References Nature. 2005 Mar 10;434(7030):234-8.  
The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs.
Research applications Reproductive Biology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nature, 434, 234-238 (2005).
RECIPIENT which wants to use the BIOLOGICAL RESOURCE for the purpose other than education or not-for-profit research is requested to enter into a Material Transfer Agreement with Osaka University ( The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the BIOLOGICAL RESOURCES. The RECIPIENT which wants to use the BIOLOGICAL RESOURCE even after five years must obtain a written consent from the DEPOSITOR again.  
Additional information
 1 Lab HP  
 2 Genotyping protocol <PCR>  
Depositor Okabe, Masaru (Osaka university)  Okabe, Masaru 
Strain Status /
(Expected delivery)

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