Strain Data Sheet
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC02102  
Type Targeted MutationCartagena   wks
Species Mus musculus  
Strain name B6.Cg-Arpc3<tm1Jtak>/JtakRbrc  
Former Common name Arpc3-KO  
H-2 Haplotype No Data  
Background strain No Data  
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Dr. Junji Takeda at Osaka University in 2005. A PGK-neo selection cassette replaced a fragment of exon 2 of Arpc3 gene.  
Strain description Arpc3 is a component of the Arp2/3 complex, which plays a major role in actin nucleation, filament binding, and Y-shaped branching to reorganize filamentous actin in response to extrinsic or intrinsic signaling for cell motility.  
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6J)  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Arpc3  
Symbol name actin related protein 2/3 complex, subunit 3  
Chromosome 5  
Common name 1110006A04Rik, Arp2/3 complex subunit p21-Arc, p21-Ar  
Symbol description No Data  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 5  
Common name neo; neomycin;  
Symbol description No Data  
References Mol Cell Biol. 2006 Aug;26(16):6185-96.  
Sleeping beauty transposon-based phenotypic analysis of mice: lack of arpc3 results in defective trophoblast outgrowth.
Research applications Cell Biology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Molecular and Cellular Biology, 26, 6185-6196 (2006).
RECIPIENT which wants to use the BIOLOGICAL RESOURCE for the purpose other than education or not-for-profit research is requested to enter into a Material Transfer Agreement with Osaka University.  
Additional information
 1 Takeda Lab HP  
 2 Genotyping protocol <PCR>  
Depositor Takeda, Junji (Osaka University)  Takeda, Junji 
Strain Status /
(Expected delivery)

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