Strain Data Sheet
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Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
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RBRC No. RBRC02251  
Type Targeted MutationCartagena   wks
Species Mus musculus  
Strain name B6.129P2-Nrp2<tm1Mkl>  
Former Common name neuropilin2 Knock out mouse  
H-2 Haplotype No Data  
ES cell line CGR8 [129P2/OlaHsd]  
Background strain C57BL/6JJcl  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Seiji Takashima, Osaka University Graduate School of Medicine in 1998. CGR8 ES cells were used.  
Strain description Neuropilin 2 gene knockout mice. Exon1 and part of the downstream intron including ATG was replaced with a lacZ-neo cassette. Neuropilin 2 expression was successfully stained with lacZ in various tissue using heterozygous mice. Homozygous mutant mice have vascular and neuronal abnormality and die in uterus or just after birth.  
Colony maintenance Hetero mice are healthy and fertile. No specific care is needed. Homo mouse is dead in uterus or soon after birth.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Nrp2  
Symbol name neuropolin 2  
Chromosome 1  
Common name 1110048P06Rik, NP-2, NP2, Npn-2, Npn2  
Symbol description No Data  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 1  
Common name neo; neomycin;  
Symbol description No Data  
 3 Symbol lacZ  
Symbol name beta-galactosidase (E. coli)  
Chromosome 1  
Common name No Data  
Symbol description E. coli beta galactosidase  
References   
Research applications Fluorescent Proteins/lacZ System,
Neurobiology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Proc. Natl. Acad. Sci. USA, 99, 3657-3662 (2002).
The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Takashima, Seiji (Osaka University Medical School and Graduate school of Frontier Biosciences)  Takashima, Seiji 
Strain Status /
Availability
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