Strain Information | |
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Image | |
BRC No. | RBRC02253 |
Type | Transgene |
Species | Mus musculus |
Strain name | C57BL/6-Tg(KRT5-Dsg3/EGFP)1 |
Former Common name | mDsg3EGFP Tg, C57BL/6, C57BL/6-Tg(hK5-mDsg3/EGFP)1 |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6JJcl |
Appearance | |
Strain development | Developed by Drs. Kouji Nishifuji anf Masayuki Amagai, Keio University School of Medicine in 2006. |
Strain description | This transgenic mouse shows the expression of the fusion protein to fuse GFP at the C terminus of full-length mouse desmoglein 3 (Dsg3), at the stratified squamous epithelium under the control of human K5 promoter. Desmoglein (Dsg) is a cadhelin type adhesive molecule to express in the desmosome of stratified squamous epithelium. It is also known as a self antigen of the pemphigus vulgaris which is one of a autoimmune bullous disease. This mouse is useful for the study of the cell adhesion function of the desmosome and pathology of autoimmune bullous disease. |
Colony maintenance | |
References |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter EGFPEnhanced Green Fluorescent Protein (Aequorea victoria)UNEGFP |
Ordering Information | |
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Donor DNA | human kerain 5 promoter, mouse desmoglein 3 cDNA, Jellyfish Green Fluorescent Protein (EGFP) cDNA |
Research application | Cell Biology Research Immunology and Inflammation Research |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR. |
Depositor | Masayuki Amagai (Keio University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |