Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jul 19, 2019
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RBRC No. RBRC02280  
Type Targeted MutationCartagena   wks
Species Mus musculus  
Strain name B6.129S4-Ephb6<tm1Tom>  
Former Common name EphB6 knock-out mouse  
H-2 Haplotype No Data  
ES cell line J1 [129S4/SvJae]  
Background strain No Data  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Dr. Toshimitsu Matsui, Kobe University in 2002.  
Strain description B6.129S4-Ephb6<tm1Tom>. EphB6, Eph receptor B6, is a member of the largest family of receptor protein kinases. Homozygous mutant mice developed normally and fertile, but T cell responses in them were compromised. This strain is useful for elucidating the EphB6 gene function.  
Colony maintenance Sibling Mating (Homozygote x Homozygote)  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Ephb6  
Symbol name Eph receptor B6  
Chromosome 6  
Common name Cekl, Mep  
Symbol description No Data  
 2 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 6  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 3 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 6  
Common name neo; neomycin;  
Symbol description No Data  
References Biochem Biophys Res Commun. 2002 Oct 18;298(1):87-94.  
Developmental expression of EphB6 in the thymus: lessons from EphB6 knockout mice.
Research applications Cancer Research,
Cell Biology Research,
Cre/loxP system,
Immunology and Inflammation Research,
Neurobiology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Biochem. Biophys. Res. Commun., 298, 87-94 (2002).
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Shimoyama M. et al. Biochem Biophys Res Commun 298; 87-94: 2002
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use or publication with the results from the use of the BIOLOGICAL RESOURCE. However, it may not be a collaboration if the research interest is out of field of the DEPOSITOR.  
Additional information
 1 Lab HP (Japanese)  
 2 Genotyping protocol <PCR>  
Depositor Matsui, Toshimitsu (Kobe University Graduate School of Medicine)  Matsui, Toshimitsu 
Strain Status /
Availability
(Expected delivery)

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