Strain Information | |
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Image | |
BRC No. | RBRC02294 |
Type | Targeted Mutation Congenic |
Species | Mus musculus |
Strain name | B6.Cg-p130Cas<tm1.2Homy> |
Former Common name | Cas-ex2<+/-> |
H-2 Haplotype | |
ES Cell line | E14 [129P2/OlaHsd] |
Background strain | |
Appearance | |
Strain development | Developed by Dr. Hiroaki Honda, Research Institute for Radiation Biology and Medicine, Hiroshima University in 2003. |
Strain description | Casp130 (Crk-associated substrate p130) knockout mice. This mice were generated by the micro-injection of the vector to express Cre recombinase into the eggs of conditional KO strain that have flanked exon 2 encoding SH3 domain of Casp130. Homozygous mutant mice are embryonic lethal. |
Colony maintenance | backcross to C57BL/6N (Heterozygote x C57BL/6NCrlCrlj) |
References | Hepatology, 52(3), 1089-1099 (2010). 20623582 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Bcar1breast cancer anti-estrogen resistance 18Bcar1<tm1.2Homy>targeted mutation 1.2, HomyCas, Crkas, p130 Cas Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Frtyeast FRT (flippase recombination target) site8Frt Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP8loxP |
Ordering Information | |
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Donor DNA | phage P1 loxP site, yeast (Saccharomyces cerevisiae) FRT site, mouse Cas genomic DNA |
Research application | Cell Biology Research Cre/loxP system FLP/frt system |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. |
Depositor | Hiroaki Honda (Tokyo Women's Medical University) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
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BRC mice in Publications |
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