Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jul 19, 2019
Health Report   PCR Protocol   Thawing Method
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RBRC No. RBRC02300  
Type Targeted MutationCartagena   wks
Species Mus musculus  
Strain name B6.129P2-Pten<tm2Mak>  
Former Common name Pten-flox mouse (C57BL/6)  
H-2 Haplotype No Data  
ES cell line E14 [129P2/OlaHsd]  
Background strain No Data  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Dr. Tak W. Mak, Ontario Cancer Institute in 2001. Deposited by Dr. Shigeo Koyasu, Keio University School of Medicine. C57BL/6N background.  
Strain description Pten is a lipid phosphatase associated with tumor suppression. This conditional knockout mice have a loxP-flanked Pten allele. Conditional Pten deficient mice can be generated by crossing with tissue-specific Cre mice.  
Colony maintenance backcross to C57BL/6 (Heterozygote x C57BL/6NTac)  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Pten  
Symbol name phosphatase and tensin homolog  
Chromosome 19  
Common name 2310035O07Rik, A130070J02Rik, MMAC1, TEP1  
Symbol description No Data  
 2 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 19  
Common name No Data  
Symbol description No Data  
References   
Research applications Cancer Research,
Cell Biology Research,
Cre/loxP system,
General Purpose  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOER (Tak W. Mak Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute E-mail: tmak@uhnresearch.ca).  
Additional information
 1 Lab HP  
 2 Genotyping protocol <PCR>  
Depositor Koyasu, Shigeo (Keio University)  Koyasu, Shigeo 
Strain Status /
Availability
(Expected delivery)

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