Strain Data Sheet
Data update: Jul 19, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC02323  
Type Targeted MutationCartagena   wks
Species Mus musculus  
Strain name B6JNrs.129S6-Atm<tm1Awb>/NrsFnt  
Former Common name B6-Atm knock-out mice  
H-2 Haplotype No Data  
Background strain C57BL/6JNrs  
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development The targeted alle was developed by Dr. A. Wynshow-Boris, NHI. The mutant mice were introduced into NRS in 1997, and then generated the Atm KO mice of C57BL/6 background by backcrossing to C57BL/6JNrs for 16 times.  
Strain description Atm, ataxia telangiectasia mutated homolog (human) gene knockout mice. Homozygous mutant mice disrupted Atm gene exhibit growth retardatuin, neurologic dysfunction, infertility, defects in T lymphocyte maturation.  
Colony maintenance Sibling Mating (Heterozygote x Wild-type)  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Atm  
Symbol name ataxia telangiectasia mutated homolog (human)  
Chromosome 9  
Common name C030026E19Rik  
Symbol description No Data  
Promoter human phosphoglycerate kinase promoter (PGK promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 9  
Common name neo; neomycin;  
Symbol description No Data  
References Cell. 1996 Jul 12;86(1):159-71.  
Atm-deficient mice: a paradigm of ataxia telangiectasia.
Research applications Cancer Research,
Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Cell. 89, 159-171 (1996).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowlidgement to Dr. Kouichi Tatsumi is requested.  
Additional information
 1 Genetic Background  
 2 Genotyping protocol <PCR>  
Depositor Tsuji, Hideo (National Institute of Radiological Sciences)  Tsuji, Hideo 
Strain Status /
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