Strain Data Sheet
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC02330  
Type Targeted Mutation CongenicCartagena  
Species Mus musculus  
Strain name NOD.Cg-Fcer1g<tm1Rav> Fcgr2b<tm1Ttk>  
Former Common name NODFcγRnull  
H-2 Haplotype No Data  
Background strain No Data  
 1 Appearance albino  
Genotype A/A c/c  
Strain development Developed by Drs. Y. Inoue and T. Takai, Tohoku University in 2004.  
Strain description FcR common gamma-chain (Fc-Rgamma) deficient mice. NOD background.  
Colony maintenance Sibling Mating (Homozygote x Homozygote)
This strain shows less severe insulitis, whereas after the onset of diabetes, homozygous and wild-type mice shows cimparable nsulitis indices.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Fcer1g  
Symbol name Fc receptor, IgE, high affinity I, gamma polypeptide  
Chromosome 1  
Common name Fce1g, FcR-gamma, FcR[g], FcRgamma, Ly-50  
Symbol description No Data  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 1  
Common name neo; neomycin;  
Symbol description No Data  
 3 Symbol Fcgr2b  
Symbol name Fc receptor, IgG, low affinity IIb  
Chromosome 1  
Common name targeted mutation 1, Toshiyuki Takai  
Symbol description No Data  
References J Immunol. 2007 Jul 15;179(2):764-74.  
Activating Fc{gamma} Receptors Participate in the Development of Autoimmune Diabetes in NOD Mice.
Research applications Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Immunol., 179, 764-774 (2007).  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Takai, Toshiyuki (Tohoku University)  Takai, Toshiyuki 
Strain Status /
(Expected delivery)

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