Strain Information | |
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Image | |
BRC No. | RBRC02333 |
Type | Transgene |
Species | Mus musculus |
Strain name | C57BL/6J-Tg(NRG1B1-TF5) |
Former Common name | NRG1B1 Tg, C57BL/6 |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6JJcl |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Dr. Miwako Ozaki, RIKEN BSI in 2003. |
Strain description | C57BL/6J-Tg(NRG1B1-TF5) mouse strain. Neuregulin-1 (NRG-1) is a neurotrophic factor that is known to regulate the development of various tissues and/or the life/death of cells through activation of the ErbB family receptor tyrosine kinases, and implicated as a potential susceptibility gene for schizophrenia. This strain is useful for investigating the function of the of NRG-1 gene. |
Colony maintenance | Backcross to C57BL/6 (Hemizygote x C57BL/6JJcl) |
References | J. Neurochem., 91, 176-188 (2004) 15379898 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Nrg1neuregulin 1 (mutant)UNNrg16030402G23Rik, ARIA, D230005F13Rik, GGF, GGFII, heregulin, HGL, Hgl, HRG, HRGalpha, NDF, SMDFEF1a-321 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter GFPGreen Fluorescent Protein (Aequorea victoria)UNEF1a-321 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter poly ASV40 polyA signalUNpoly A |
Ordering Information | |
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Donor DNA | CMV Promoter, Mouse Neuregulin-1beta cDNA, Jellyfish GFP cDNA, SV40 polyA Signal |
Research application | Fluorescent Proteins/lacZ System Neurobiology Research |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from Dr. Miwako OZAKI (Fax: 03-5272-1208). The RECIPIENT must contact Dr. Miwako OZAKI and RIKEN BSI in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Miwako Ozaki (RIKEN) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |