Strain Data Sheet
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Data update: Jul 19, 2019
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RBRC No. RBRC02334  
Type TransgeneCartagena   wks
Species Mus musculus  
Strain name B6.DBA/2J-Tg(NRGB1-TD4)  
Former Common name NRG1B1 Del Mutant, D2B6  
H-2 Haplotype No Data  
Background strain C57BL/6JJcl  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Dr. Miwako Ozaki, RIKEN Brain Science Institute in 2003.  
Strain description B6.B6D2-Tg(EF1A-GFP/Nrg1beta1)TD4. Neuregulin-1 (NRG-1) is a neurotrophic factor that is known to regulate the development of various tissues and/or the life/death of cells through activation of the ErbB family receptor tyrosine kinases, and implicated as a potential susceptibility gene for schizophrenia. This transgenic mice express a mutant NRG1beta1 (NRGB1) gene under the control of the EF1a-321 promoter. This strain is useful for investigating the function of the of NRG-1 gene.  
Colony maintenance Carrier x Noncarrier  
Health Report
Gene Details
Promoter No Data  
 1 Symbol poly A  
Symbol name SV40 poly A signal  
Chromosome UN  
Common name No Data  
Symbol description No Data  
Promoter EF1a-321  
 2 Symbol Nrg1  
Symbol name neuregulin 1 (mutant)  
Chromosome UN  
Common name 6030402G23Rik, ARIA, D230005F13Rik, GGF, GGFII, heregulin, HGL, Hgl, HRG, HRGalpha, NDF, SMDF  
Symbol description No Data  
 3 Symbol GFP  
Symbol name Green Fluorescent Protein (Jellyfish)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
References J Neurochem 2004 Oct;91(1):176-88.  
Protein processing and releases of neuregulin-1 are regulated in an activity-dependent manner.
Research applications Fluorescent Proteins/lacZ System,
Neurobiology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from Dr. Miwako OZAKI (Fax: 03-5272-1208).
The RECIPIENT must contact Dr. Miwako OZAKI and RIKEN BSI in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC's MTA. Please also read Schedule B.  
 2 Genotyping protocol <PCR>  
Depositor Ozaki, Miwako (RIKEN Brain Science Institute)  Ozaki, Miwako 
Strain Status /
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