Strain Data Sheet
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Data update: Aug 20, 2019
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RBRC No. RBRC02339  
Type Transgene CongenicCartagena   wks
Species Mus musculus  
Strain name B6.Cg-Tg(Tec-p210 BCR/ABL1)1Homy  
Former Common name p210 Tg  
H-2 Haplotype No Data  
Background strain C57BL/6NCrlCrlj  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Drs. Honda and Hirai, University of Tokyo in 1998.  
Strain description This transgenic strain expresses the p210 BCR/ABL1 gene. Tg mice show marked granulocyte hyperplasia and develop myeloproliferative disorders closely resembling human chronic myelogenous leukemia.  
Colony maintenance Backcross to C57BL/6 (Hemizygote x C57BL/6NCrlCrlj)  
Health Report
Gene Details
Promoter No Data  
 1 Symbol poly A  
Symbol name SV40 poly A siganl  
Chromosome UN  
Common name No Data  
Symbol description No Data  
Promoter mouse Tec  
 2 Symbol BCR/ABL1  
Symbol name p210 bcr/abl1 (human)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
References Oncogene. 2008 May 29;27(24):3465-74. Epub 2008 Jan 14.


  
Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice.
Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice.
Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice.
Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice.
Research applications Cancer Research,
Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.  
Additional information
 1 Lab HP (Japanese)  
 2 Genotyping protocol <PCR>  
Depositor Honda, Hiroaki (Tokyo Women's Medical University)  Honda, Hiroaki 
Strain Status /
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