Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
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RBRC No. RBRC02368  
Type Targeted Mutation CongenicCartagena  
Species Mus musculus  
Strain name B6.Cg-Nr1i2<tm1(NR1I2)>  
Former Common name No Data  
H-2 Haplotype No Data  
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Jun Kanno, National Institute of Health Sciences in 2006. TT2 ES cells were used. The mutant mice were crossed to C57BL/6. Cre- recombined allele (RBRC02367) type mice were generated from Targeted allele type (RBRC02368) mice by crossing with CAG-Cre mice to removed a floxed neo cassette.  
Strain description hSXRki mice in which the ligand binding domain (LBD) of human SXR was knocked-into the mouse SXR gene. These umanized mouse model is a useful tool for monitoring the systemic response induced by human-selective SXR ligans. Cre- recombined allele (RBRC02367), Targeted allele type (RBRC02368).  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Nr1i2  
Symbol name Nuclear receptor subfamily 1, group I, member 2  
Chromosome 16  
Common name No Data  
Symbol description No Data  
 2 Symbol GH  
Symbol name Growth hormone polyA (Bovine)  
Chromosome 16  
Common name No Data  
Symbol description No Data  
 3 Symbol NR1I2  
Symbol name Nuclear receptor subfamily 1, group I, member 2 (human)  
Chromosome 16  
Common name No Data  
Symbol description No Data  
 4 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 16  
Common name No Data  
Symbol description No Data  
 5 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 16  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 6 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 16  
Common name neo; neomycin;  
Symbol description No Data  
References   
Research applications Cre/loxP system  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Toxicol. Sci., 37, 373-380 (2012).
For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Kanno, Jun (National Institute of Health Sciences)  Kanno, Jun 
Strain Status /
Availability
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