Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Aug 20, 2019
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RBRC No. RBRC02378  
Type Targeted Mutation CongenicCartagena   wks
Species Mus musculus  
Strain name B6.Cg-Nox1<tm1Cyn>  
Former Common name Nox1 KO mouse, Nox1 knockout mouse  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Drs. Chihiro Yabe-Nishimura, Kuniharu Matsuno, Kazumi Iwata at Kyoto Prefectual University of Medicine in 2003.  
Strain description Nox1 deficient mice. Nox1 gene is a member of the NADPH- dependent superoxide producing enzyme family, which is involved in the production of active oxygen in nonphagocytic cells on the intestine epithelium and vascular smooth muscle.  
Colony maintenance Backcross to C57BL/6 (Heterozygous or Hemizygote x C57BL/6CrSlc)  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Nox1  
Symbol name NADPH oxidase  
Chromosome X  
Common name GP91 phox homolog  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome X  
Common name neo; neomycin;  
Symbol description No Data  
References Circulation 2005 Oct 25;112(17):2677-85.  
Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice.
Research applications Cardiovascular Research,
Metabolism Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Circulation, 112, 2677-2685 (2005).
The BIOLOGICAL RESOURCE should not be utilized for the application of any patent for commercial purposes without an additional agreement with the DEPOSITOR. The RECIPIENT should not distribute the BIOLOGICAL RESOURCE including any progeny, unmodified derivatives, or any derivatives or genetically engineered modification if such derivative or modification is substantially based on and incorporates an essential element of the BIOLOGICAL RESOURCE to any other individual or entity without the DEPOSITOR's written consent. The RECIPIENT should inform results obtained using the BIOLOGICAL RESOURCE and discuss the authorship of the work with the DEPOSITOR prior to publication.  
Additional information
 1 Lab HP (Japanese)  
 2 Genotyping protocol <PCR>  
Depositor Yabe, Chihiro (Kyoto Prefectural University of Medicine)  Yabe, Chihiro 
Strain Status /
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