Strain Information | |
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Image | |
BRC No. | RBRC02411 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129S2-Ptn<tm1Tmu> |
Former Common name | Ptn-KO/C57BL/6J |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Drs. Muramatsu H. and Muramatsu T., Nagoya University in 2001. |
Strain description | Pleiotrophin (PTN) knock-out mice, Ptn is a low molecular weight protein that regulates cell growth, survival and migration and other activities of responding cells. Ptn gene strongly expresses in the brain at the later mouse embryogenesis, In the human, it is known that the expression of Ptn gene is observed at the ischemic injury in various cancer. |
Colony maintenance | Backcross to C57BL/6 (Heterozygote x C57BL/6JJmsSlc) |
References | Genes Cells, 11, 1405-1417 (2006). 17121547 Lab. Invest., 86, 645-653 (2006). 16619002 Liver Int., 24, 484-491 (2004). 15482347 J. Biochem., 132, 359-371 (2002). 12204104 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Ptnpleiotrophin6Ptn<tm1Tmu>targeted mutation 1, Takashi MuramatsuHB-GAM, HBGF-8, heparin-binding growth factor 8, heparin-binding growth-associated molecule, Osf-1, Osf1 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)6neo; neomycin;polyoma virus thymidine kinase gene promoter (tk promoter) |
Ordering Information | |
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Donor DNA | polyoma virus thymidine kinase gene promoter, E. coli neomycin resistance gene, mouse Ptn genomic DNA |
Research application | Cancer Research Cell Biology Research Neurobiology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Liver Int., 24, 484-491 (2004). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR (Dr. Hisako Muramatsu) is requested. |
Depositor | Hisako Muramatsu (Nagoya University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |