Strain Data Sheet
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Data update: Aug 20, 2019
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RBRC No. RBRC02415  
Type TransgeneCartagena   wks
Species Mus musculus  
Strain name C57BL/6-Tg(TRE-GFP)392Yasu  
Former Common name β-catenin/Tcf reporter mice  
H-2 Haplotype No Data  
Background strain C57BL/6JJcl  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Yasuhiro Yamada, Gifu University Graduate School of Medicine in 2007. The transgene was injected into the pronuclei of C57BL/6 fertilized eggs. Line 392 (main line) (RBRC02415), line 622 (rbrc02416) and line 628 (RBRC02417).  
Strain description Beta-catenin/Tcf reporter mice. These mice express GFP gene under the control of the Tcf/Lef binding sites and a minimal thymidine kinase promoter from the TOPFLASH plasmid. Immunohistochemistry with a GFP antibody can be used to assess the Tg expression in the intestine. In other organs except for the intestine. In the splenocytes, expression of GFP was observed by FACS analysis, In other organs, the GFP expression patterns are not examined yet.  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol No Data  
Symbol name SV40 polyA  
Chromosome No Data  
Common name No Data  
Symbol description No Data  
Promoter Tcf binding element, herpes simplex virus thymidine kinase promoter (HSV tk promoter)  
 2 Symbol GFP  
Symbol name Green Fluorescent Protein (Jellyfish)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
References Cancer Res. 2007 May 1;67(9):4079-87.
Carcinogenesis. 2008 Mar;29(3):666-72. Epub 2008 Jan 19.  
Development of gastric tumors in Apc(Min/+) mice by the activation of the beta-catenin/Tcf signaling pathway.
Development of gastric tumors in Apc(Min/+) mice by the activation of the beta-catenin/Tcf signaling pathway.
Research applications Cancer Research,
Cell Biology Research,
Developmental Biology Research,
Fluorescent Proteins/lacZ System,
General Purpose,
Tet system  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers.  
Additional information
 1 GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC's MTA. Please also read Schedule B.  
Depositor Yamada, Yasuhiro (Gifu University, Graduate School of Medicine)  Yamada, Yasuhiro 
Strain Status /
Availability
(Expected delivery)

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