Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
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RBRC No. RBRC02428  
Type Targeted Mutation and TransgeneCartagena  
Species Mus musculus  
Strain name B6.Cg-Kras<tm1Mok> Trp53<tm2Mok> Tg(hKrasPAC)1Mok  
Former Common name mouse K-ras, p53 KO, K-ras(PAC)Tg, B6-Kras KO/p53 KO/KrasPAC Tg  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.  
Strain description Triple mutant mice having a Kras gene knockout, p53 (Trp53) knockout (lacZ reporter) and human KRAS transgenene.  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 11  
Common name neo; neomycin;  
Symbol description No Data  
 2 Symbol Trp53  
Symbol name transformation related protein 53  
Chromosome 11  
Common name p53  
Symbol description No Data  
 3 Symbol lacZ  
Symbol name beta-galactosidase (E. coli)  
Chromosome 11  
Common name No Data  
Symbol description E. coli beta galactosidase  
 4 Symbol Kras  
Symbol name v-Ki-ras2 Kirsten rat sacroma viral oncogene homolog  
Chromosome 6  
Common name K-ras, Ki-ras, Kras-2, Kras2  
Symbol description No Data  
 5 Symbol KRAS  
Symbol name v-Ki-ras2 Kirsten rat sacroma viral oncogene homolog (human)  
Chromosome UN  
Common name K-ras, Ki-ras, Kras-2, Kras2  
Symbol description No Data  
References Biochem Biophys Res Commun. 1994 Jul 29;202(2):830-7.
Oncogene. 1997 Sep 4;15(10):1151-9.  
Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and mice by using two steps of homologous recombination.
Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and mice by using two steps of homologous recombination.
Research applications Cancer Research,
Cell Biology Research,
Immunology and Inflammation Research,
Mouse Models for Human Disease  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Oncogene, 15, 1151-1159 (1997). Biochem. Biophys. Res. Commun., 202, 830-837 (1994).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
Depositor Sasaoka, Toshikuni (Niigata university)  Sasaoka, Toshikuni 
Strain Status /
Availability
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