Strain Data Sheet
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Data update: May 20, 2019
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RBRC No. RBRC02460  
Type Targeted Mutation and TransgeneCartagena  
Species Mus musculus  
Strain name B6.Cg-Hras1<tm1Mok> Tg(cre) Tg(lacZ)  
Former Common name H-ras-KO, Cre, LacZTg, B6-Hras KO/Cre lacZ Tg  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.  
Strain description Triple mutant mice having a Kras gene knockout, cre and lacZ transgene.  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Hras1  
Symbol name Harvey rat sarcoma virus oncogene 1  
Chromosome 7  
Common name c-H-ras, c-rasHa, H-ras, Ha-ras, Harvey-ras, Hras-1, ras  
Symbol description No Data  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome No Data  
Common name neo; neomycin;  
Symbol description No Data  
 3 Symbol cre  
Symbol name Phage P1 Cre recombinase  
Chromosome No Data  
Common name No Data  
Symbol description No Data  
 4 Symbol lacZ  
Symbol name beta-galactosidase (E. coli)  
Chromosome No Data  
Common name No Data  
Symbol description E. coli beta galactosidase  
References Oncogene. 2000 Jun 15;19(26):2951-6.  
Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Oncogene, 19, 2951-2956 (2000).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
Depositor Sasaoka, Toshikuni (Niigata university)  Sasaoka, Toshikuni 
Strain Status /
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