Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Aug 20, 2019
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RBRC No. RBRC02473  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6;129S-Grin2a<tm1Nak> Hras1<tm1Mok>  
Former Common name B6-NR2A/Hras KO  
H-2 Haplotype No Data  
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.  
Strain description NR2A (Grin2a) and Hras genes double knockout mice.  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Grin2a  
Symbol name glutamate receptor, ionotropic, NMDA2A (epsilon 1)  
Chromosome 16  
Common name No Data  
Symbol description No Data  
 2 Symbol Hras  
Symbol name Harvey rat sarcoma virus oncogene  
Chromosome 7  
Common name No Data  
Symbol description No Data  
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)  
 3 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 16  
Common name neo; neomycin;  
Symbol description No Data  
References J Neurosci. 1996 Dec 15;16(24):7859-67.
Oncogene. 2000 Jun 15;19(26):2951-6.  
Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit.
Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit.
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Neurosci., 16, 7859-7867 (1996). Oncogene, 19, 2951-2956 (2000).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
Depositor Sasaoka, Toshikuni (Niigata university)  Sasaoka, Toshikuni 
Strain Status /
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