Strain Data Sheet
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Data update: Jul 19, 2019
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RBRC No. RBRC02477  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6;129-Grin2a<tm1Nak> Grin2b<tm1Stl> Drd2<tm1Mok> Drd3<tm1Mok> Drd4<tm1Mok>  
Former Common name B6-NR2A/NR2B/D2R/D3R/D4R KO  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.  
Strain description NR2A (Grin2a), NR2B (Grin2b), D2R (Drd2), D3R (Drd3) and D4R (Drd4) genes multiple knockout mice.  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Drd3  
Symbol name dopamine receptor 3  
Chromosome 16  
Common name D3 receptor, D3R  
Symbol description No Data  
 2 Symbol Grin2a  
Symbol name glutamate receptor, ionotropic, NMDA2A (epsilon 1)  
Chromosome 16  
Common name No Data  
Symbol description No Data  
 3 Symbol Grin2b  
Symbol name glutamate receptor, ionotropic, NMDA2B (epsilon 2)  
Chromosome 6  
Common name GluRepsilon2, NMDAR2B, Nmdar2b, NR2B  
Symbol description No Data  
 4 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 6  
Common name neo; neomycin;  
Symbol description No Data  
 5 Symbol Drd4  
Symbol name dopamine receptor 4  
Chromosome 7  
Common name D4R, Drd-4  
Symbol description No Data  
 6 Symbol Ecogpt  
Symbol name E.coli xanthine phosphoribosyltransferase  
Chromosome 7  
Common name No Data  
Symbol description No Data  
 7 Symbol Drd2  
Symbol name dopamine receptor 2  
Chromosome 9  
Common name D2 receptor, D2R, Drd-2  
Symbol description No Data  
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)  
 8 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 16  
Common name neo; neomycin;  
Symbol description No Data  
 9 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 9  
Common name neo; neomycin;  
Symbol description No Data  
Promoter mouse RNA polymerase II large subunit promoter  
 10 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 7  
Common name neo; neomycin;  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 11 Symbol Ecogpt  
Symbol name E.coli xanthine phosphoribosyltransferase  
Chromosome 16  
Common name No Data  
Symbol description No Data  
References Genes Cells. 1996 Feb;1(2):253-68.
J Neurosci. 1996 Dec 15;16(24):7859-67.  
Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary.
Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary.
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Nerurosci., 16, 7859-7867 (1996).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Drs. Motoya Katsuki and Toshikuni Sasaoka is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
Depositor Sasaoka, Toshikuni (Niigata university)  Sasaoka, Toshikuni 
Strain Status /
Availability
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