Strain Information | |
---|---|
Image | |
BRC No. | RBRC02598 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6;129-Mutyh<tm1Yun> |
Former Common name | MYH KO |
H-2 Haplotype | |
ES Cell line | CCE28 [129/Sv] |
Background strain | |
Appearance | |
Strain development | Developed by Yusaku Nakabeppu, Medical Institute of Bioregulation, Kyushu University. CCE28 ES cells derived from 129/Sv were used to generate the knockout mice. The mice were crossed to C57BL/6. |
Strain description | MYH (Mutyh) gene knockout mice. Exons 8 to 15 were replaced with a pol II neo cassette. Homozygous mutant mice show decreased susceptibility to neuronal excitotoxicity. |
Colony maintenance | Heterozygote x Wild-type [C57BL/6JJcl] |
References | J. Biol. Chem., 278, 38121-38124 (2003). 12917422 |
Health Report | |
---|---|
Examination Date / Room / Rack |
Gene | |
---|---|
Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)4 |
Ordering Information | |
---|---|
Donor DNA | MYH (mut Y homologue), E. coli neo, RNA polymerase II promoter, polyA |
Research application | Neurobiology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 278, 38121-38124 (2003). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Toshikuni Sasaoka (Niigata University) |
Strain Status | Frozen embryos |
Strain Availability | Recovery and QC required prior to distribution |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
---|
No Data |