Strain Data Sheet
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC02760  
Type Targeted Mutation CongenicCartagena   wks
Species Mus musculus  
Strain name B6.Cg-Atg7<tm1.1Tchi>  
Former Common name C57BL/6-Atg7+/-  
H-2 Haplotype No Data  
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]  
Background strain No Data  
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Drs. Komatsu and Chiba, Tokyo Metropolitan Institute of Medical Science.  
Strain description Atg7, autophagy-related 7 gene knock-out mice. Atg7 is essential for ATG conjugation, LC3 modification systems, and autophagosome formation. Homozygous mutant mice die within 1 day of delivery.  
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Homozygous mutant mice die within 1 day after birth.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Atg7  
Symbol name autophagy-related 7 (yeast)  
Chromosome 6  
Common name 1810013K23Rik, Apg7l  
Symbol description No Data  
 2 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 6  
Common name No Data  
Symbol description No Data  
References J Cell Biol 2005 May 9;169(3):425-34. Epub 2005 May 2.  
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice.
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Cell Blol., 169, 425-434 (2005).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. The RECIPIENT of BIOLOGICAL RESOURCE, Who belongs to a profit organization must obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents use with the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 Lab HP (Japanese)  
 2 Mouse of the Month Jun 2012, Mouse of the Month Oct 2016
Genetic Background  
 3 Genotyping protocol <PCR>  
Depositor Komatsu, Masaaki (Tokyo Metropolitan Institute of Medical Science)  Komatsu, Masaaki 
Strain Status /
(Expected delivery)

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