Strain Data Sheet
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Data update: Jul 19, 2019
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RBRC No. RBRC02781  
Type Transgene CongenicCartagena  
Species Mus musculus  
Strain name B6.Cg-Cd8a<a> Tg(Tcra2C,Tcrb2C)1Dlo  
Former Common name 2C TCR, B6-Cd8a 2CTCR Tg  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development The transgene was developed by Dennis Loh, Washington University School of Medicine in 1988. The mice were deposited by Takanori Teshima, Kyushu University Hospital, through Paul Martin, Fred Hutchinson Cancer Research Center. H-2b and Ly2.1 (Cd8.1) background.  
Strain description 2C TCR transgenic mice expressing the alpha beta antigen receptor from the cytotoxic T-lymphocyte clone 2C. Ly2.1 (Cd8.1) congenic line.  
Colony maintenance Tg : Carrier x Noncarrier ; Ly2 : Homozygote x Homozygote  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Cd8a  
Symbol name CD8 antigen, alpha chain  
Chromosome 6  
Common name No Data  
Symbol description No Data  
 2 Symbol Tcra2C  
Symbol name T cell receptor alpha chain  
Chromosome UN  
Common name No Data  
Symbol description No Data  
 3 Symbol Tcrb2C  
Symbol name T cell receptor beta chain  
Chromosome UN  
Common name No Data  
Symbol description No Data  
 4 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
References Nature. 1988 Sep 15;335(6187):271-4.
  
Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice.
Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice.
Research applications Immunology and Inflammation Research  
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Teshima, Takanori (Kyushu university hospital)  Teshima, Takanori 
Strain Status /
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