Strain Data Sheet
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Data update: Aug 20, 2019
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RBRC No. RBRC02830  
Type Transgene CongenicCartagena   wks
Species Mus musculus  
Strain name B6.B6C3-Tg(Th-SNCA*140m)01-1Yosh  
Former Common name Syn140m-01-1, B6.Cg-Tg(Th-SNCA*)01-1Yosh  
H-2 Haplotype No Data  
Background strain C57BL/6JJcl  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Masaki Wakamatsu, Makoto Yoshimoto, Taisho Pharmaceutical Co., Ltd. in 2001. The transgene was injected into the pronuclei of B6C3F1 fertilized eggs. The mutant mice were backcrossed C57BL/6.  
Strain description Th-SCNA transgenic mice expressing human alpha synuclein under the control of tyrosine hydroxylase promoter. Syn130m line (RBRC02829) having a human alpha synuclein sequence with an Ala53Thr point mutation and a lacking of 10 amino acids at the C-terminus, Syn140m line (RBRC02830) having a human alpa synuclein sequence with an Ala 53Thr point mutation. Syn130m line (RBRC02829) is useful as a model of Parkinson Disease. Syn130m Tg mice exhibit decreased dopamine level and dopaminergic neuron number. Motor activity and exploratory behavior are reduced compared to controls. Tg homozygous mice are postnatal lethal. Syn140m line (RBRC02830) is available as a control of Syn130m line. Syn140m Tg mice show no obvious abnormality.  
Colony maintenance Carrier x Noncarrier [C57BL/6JJcl]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol No Data  
Symbol name SV40 polyA-additional signal  
Chromosome UN  
Common name No Data  
Symbol description No Data  
 2 Symbol HBB2  
Symbol name rabbit beta-globin intron  
Chromosome UN  
Common name No Data  
Symbol description No Data  
Promoter rat tyrosine hydroxylase (TH) promoter  
 3 Symbol SNCA  
Symbol name synuclein, alpha (human)  
Chromosome UN  
Common name synuclein, alpha  
Symbol description No Data  
References J Neurosci Res. 2007 Apr 26;.
  
Accumulation of phosphorylated alpha-synuclein in dopaminergic neurons of transgenic mice that express human alpha-synuclein.
Accumulation of phosphorylated alpha-synuclein in dopaminergic neurons of transgenic mice that express human alpha-synuclein.
Research applications Mouse Models for Human Disease  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Neurosci. Res., 85, 1819-1825 (2007).  
Additional information
 1 No Data  
Depositor Taisho Pharmaceutical Co.,Ltd., (Taisho Pharmaceutical Co., Ltd.)  Taisho Pharmaceutical Co.,Ltd., 
Strain Status /
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