Strain Data Sheet

RBRC02846

Strain Information

Image
BRC No.RBRC02846
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain name129S6/SvEvTac-Crx<tm1Clc>
Former Common nameCRX K.O.
H-2 Haplotype
ES Cell line
Background strain129S6/SvEvTac
Appearancelight-bellied agouti [A<w>/A<w> B/B C/C]
Strain developmentDeveloped by Dr. Takahisa Furukawa, Harvard Medical School in 1999.
Strain descriptionCrx gene knockout mice. Homozygous mutant mice lack a outer segment of retinal photoreceptor.
Colony maintenanceSibling x Sibling (Homozygote x Homozygote)Homozygous mutant mice are viable and fertile
ReferencesNat. Genet., 23, 466-470 (1999). 10581037

Health Report

Examination Date / Room / Rack2022/07/11Room:3-BRack:K
2022/06/13Room:3-BRack:K
2022/04/11Room:3-BRack:K

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Crxcone-rod homeobox containig gene7Crx<tm1Clc>targeted mutation 1, Constance L Cepkocone-rod homeobox containg gene

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)7neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter)

Ordering Information

Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, SV40 polyA, mouse Crx genomic DNA
Research application
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Genet., 23, 466-470 (1999).
DepositorTakahisa Furukawa (Osaka Bioscience Institute)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

Iura Y, Udo H.
Behavioral analyses of visually impaired Crx knockout mice revealed sensory compensation in exploratory activities on elevated platforms.
Behav Brain Res 258 1-7(2014) 24140563