Strain Data Sheet
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC02849  
Type Targeted Mutation CongenicCartagena   wks
Species Mus musculus  
Strain name B6.Cg-Ern1tm1Dron  
Former Common name Irel alpa knockout mouse +/- strain:129/C57BL/Black Swiss Webster  
H-2 Haplotype No Data  
Background strain No Data  
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Dr. David Ron, New York University School of Medicine. Gene targeting was achieved in W4 ES cells.  
Strain description Ern1, endoplasmic reticulum (ER) to nucleus signaling 1 gene knock-out mice. Homozygous Ern1 mutant mice are embryonic lethal during organogenesis.  
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Homozygotes are embryonic lethal.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Ern1  
Symbol name endoplasmic reticulum (ER) to nucleus signaling 1  
Chromosome 11  
Common name targeted mutation 1, David Ron  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 11  
Common name neo; neomycin;  
Symbol description No Data  

Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Science, 287, 664-666 (2000). Nature, 415, 92-96 (2002).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
DEPOSITOR hereby excludes any and all warranties, implied or express, including warranties of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE or of non-infringement of patents or other proprietary right. The sample of BIOLOGICAL RESOURCE is provided "as is". In no event shall DEPOSITOR be liable for direct, indirect, special, incidental or consequential damages in connection with the BIOLOGICAL RESOURCE. RECIPIENT and RIKEN BRC will indemnify and hold DEPOSITOR harmless from any claims or liability resulting from the use of the BIOLOGICAL RESOURCE by you. Prior to filing an application for a patent, or intellectual property or other rights based on the results of research using the BIOLOGICAL RESOURCE, the recipient shall acquire the consent form the DEPOSITOR for such application.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Ron, David (New York University School of Medicine)  Ron, David 
Strain Status /
(Expected delivery)

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