Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC03438  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6;129P2-Arx<tm1Kki>/6Rbrc  
Former Common name Arx-6 KO  
H-2 Haplotype No Data  
ES cell line E14TG2a [129P2/OlaHsd]carries Hprt  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Kunio Kitamura, Mitsubishi Kagaku Institute of Life Sciences. E14 ES cells were used to generate the mutant mice.  
Strain description Arx gene knockout mice. A lacZ-neo cassette was inserted into the exon 2 of Arx gene. Hemizygous (-/Y) mutant males die within 12 hrs after birth. Main line: Arx-6 KO (RBRC03438).  
Colony maintenance Heterozygote (female) x Wild-type (male)[C57BL/6JJcl]  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol No Data  
Symbol name SV40 PolyA signal  
Chromosome X  
Common name No Data  
Symbol description No Data  
 2 Symbol Arx  
Symbol name aristaless related homeobox  
Chromosome X  
Common name No Data  
Symbol description No Data  
 3 Symbol IRES  
Symbol name internal ribosomal entry site (EMCV)  
Chromosome X  
Common name No Data  
Symbol description No Data  
 4 Symbol lacZ  
Symbol name beta-galactosidase (E. coli)  
Chromosome X  
Common name No Data  
Symbol description No Data  
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)  
 5 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome X  
Common name No Data  
Symbol description No Data  
References Nat Genet 2002 Nov;32(3):359-69. Epub 2002 Oct 15.  
Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans.
Research applications Fluorescent Proteins/lacZ System,
Mouse Models for Human Disease  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The BIOLOGICAL RESOURCE shall be used only for academic research purposes by
a non-profit organization.
The RECIPIENT of a non-profit organization must prior contact RIKEN BRC and
negotiate with Mitsubishi Chemical Corporation to use the BIOLOGICAL
RESOURCE for purposes of other than academic research.
In publishing the research results to be obtained by use of the BIOLOGICAL
RESOURCE in relevant journals and meetings, the RECIPIENT must stipulate the
source of the BIOLOGICAL RESOURCE and an acknowledgment to Mitsubishi
Chemical Corporation.
The RECIPIENT agrees that RIKEN BRC informs annually to Mitsubishi Chemical
Corporation of RECIPIENT organization, RECIPIENT name, the specific research
purpose and the date of distribution.  
Additional information
 1 No Data  
Depositor Kitamura, Kunio (Mitsubishi Chemical Corporation)  Kitamura, Kunio 
Strain Status /
Availability
(Expected delivery)

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