Strain Data Sheet
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC03558  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name 129.Cg-Pax7<tm1Pgr>  
Former Common name Pax129, 129-Pax7 KO  
H-2 Haplotype No Data  
Background strain No Data  
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Peter Gruss, Max Planck Institute for Biophysical Chemistry. The mutant mice were backcrossed 129 over 20 times by Naohiro Hashimoto, National Center for Geriatrics and Gerontology.  
Strain description Pax7 gene knockout mice. The first exon of the paired box was replaced with a neo cassette (RBRC03558) and lacZ-neo cassette (RBRC03559), respectively. In the C57BL/6 background, most homozygous mutant mice die within 3 weeks after birth (survival rate is below 10%). On the other hand, in the 129 background (RBRC03558 and RBRC03559), approximately 50% of mutant mice die within 3 weeks after birth (details unknown). Heterozygous mutant mice for lacZ repoter Pax7<tm2Pgr> (RBRC03559) show negative X-gal staining in the muscle satellite cells.  
Colony maintenance Heterozygote x Wild-type [or Crossing to 129<+Ter>/SvJcl]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Pax7  
Symbol name paired box gene 7  
Chromosome 4  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (Klebsiella pneumoniae)  
Chromosome 4  
Common name No Data  
Symbol description No Data  

Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER of the Pax7tm1Pgr allele (Peter Gruss, Max Planck Institute for Biophysical Chemistry). (  
Additional information
 2 Genotyping protocol <PCR>  
Depositor Hashimoto, Naohiro (National Institute for Longevity Sciences)  Hashimoto, Naohiro 
Strain Status /
(Expected delivery)

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