Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
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  Mouse Marking
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RBRC No. RBRC04021  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129-Dnase2a<tm1Osa> Ifnar1<tm1Agt>  
Former Common name DNaseII / IFN-IR double knock out  
H-2 Haplotype No Data  
ES cell line R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]  
Background strain C57BL/6  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Kohki Kawane and Shigekazu Nagata, Graduate School of Medicine, Kyoto University in 2004. C57BL/6 background (over N8 generations).  
Strain description DNaseII/IFN-IR double knockout mice. Double homozygous mutant mice develop polyarthritis as age.  
Colony maintenance Dnase2a: Heterozygote x Wild-type; Ifnar1: Homozygote x Homozygote  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Ifnar1  
Symbol name interferon (alpha and beta) receptor 1  
Chromosome 16  
Common name No Data  
Symbol description No Data  
 2 Symbol Dnase2a  
Symbol name deoxyribonuclease II alpha  
Chromosome 8  
Common name No Data  
Symbol description No Data  
 3 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 8  
Common name No Data  
Symbol description No Data  
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)  
 4 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 16  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 5 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 8  
Common name No Data  
Symbol description No Data  
References Nat Immunol. 2005 Jan;6(1):49-56. Epub 2004 Nov 28.
Nature. 2006 Oct 26;443(7114):998-1002.
  
Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA.
Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA.
Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA.
Research applications Cre/loxP system,
Mouse Models for Human Disease  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nature, 443, 998-1002 (2006). Nat. Immunol., 6, 49-56 (2005).
RECIPIENT may only use the BIOLOGICAL RESOURCE for non-commercial academic research purpose. The RECIPIENT should negotiate with the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 Lab HP  
 2 Mouse of the Month Aug 2012  
 3 Genotyping protocol <PCR>  
Depositor Nagata, Shigekazu (Osaka University)  
Strain Status /
Availability
(Expected delivery)

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