Strain Data Sheet
Data update: Aug 20, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC04436  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129-Msi2<tm1Okn>  
Former Common name No Data  
H-2 Haplotype No Data  
Background strain No Data  
 1 Appearance No Data  
Genotype No Data  
Strain description Msi2 deficient mice
Msi2 deficient mice survive to adult and show poor weight gain, low spontaneous movement and sensory dysfunction, with abnormal PNS development. The cause of the phenotype is thought to be poor neural fiber innervations of specific sensory neuron from DRG to spinal cord. These phenotypes are observed both background (C57BL/6J and CD-1) and detailed analyses were performed in CD-1 background.
Msi2 deficient male mice show azoospermia and are infertile. Because the movement of sperm taken from epidermis of Msi2 null male was bad, in vitro fertilization was not successful. Msi2 deficient female mice are fertile; however, probability of pregnancy is poor presumably due to the low spontaneous activity. (All date of Msi2 deficient mice are in preparation by Shibata S. et al)  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Msi2  
Symbol name Musashi homolog 2 (Drosophila)  
Chromosome 11  
Common name No Data  
Symbol description No Data  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome No Data  
Common name neo; neomycin;  
Symbol description No Data  
 3 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome No Data  
Common name No Data  
Symbol description No Data  
 4 Symbol poly A  
Symbol name poly A  
Chromosome No Data  
Common name No Data  
Symbol description No Data  
References No Data  
Research applications Cell Biology Research,
Neurobiology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
For use of the BIOLOGICAL RESOURCE, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.  
Additional information
 1 Lab HP  
 2 Genotyping protocol <PCR>  
Depositor Okano, Hideyuki (Keio University School of Medicine)  Okano, Hideyuki 
Strain Status /
(Expected delivery)

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