Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC04545  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name 129-Rnf135<tm1>  
Former Common name Riplet KO  
H-2 Haplotype No Data  
ES cell line EGR-05 [129S2]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Hiroyuki Oshiumi, Graduate School of Medicine, Hokkaido University. EGR05 ES cells were used to generate the mutant mice.  
Strain description Rnf135 (Riplet) gene knockout mice. Exons 2 and 3 were replaced with a PGK-neo cassette. 129 background (RBRC04545), C57BL/6 mixed background (RBRC06432).  
Colony maintenance Homozygote x Homozygote  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Rnf135  
Symbol name ring finger protein 135  
Chromosome 11  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 11  
Common name No Data  
Symbol description No Data  
References J Biol Chem. 2009 Jan 9;284(2):807-17. Epub 2008 Nov 18.  
Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection.
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Biol. Chem., 284, 807-817 (2009).  
Additional information
 1 Lab HP (Japanese)  
 2 Genotyping protocol <PCR>  
Depositor Oshiumi, Hiroyuki (Hokkaido University)  Oshiumi, Hiroyuki 
Strain Status /
Availability
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