Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jul 19, 2019
Health Report   PCR Protocol   Thawing Method
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RBRC No. RBRC04664  
Type TransgeneCartagena  
Species Mus musculus  
Strain name 129;FVB-Tg(PDGFB-Ptn)2Rau  
Former Common name No Data  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Dveloped by Dr. Heikki Rauvala, Institute of Biotechnology and Department of Biosciences, University of Helsinki. PDGF-beta promoter followed by rabbit beta-globulin intron and HB-GAM cDNA and sv40 poly-A-tail. Pavlov et al. (2002), Molecular and Cellular Neuroscience; Vol. 20, pp. 330-342.  
Strain description Transgenic mice overexpressing HB-GAM (pleiotrophin). Attenuated long-term potentiation (LTP) in hippocampus. Faster learning in water maze and decreased anxiety in elevated plus-maze compared to the wild-type mice. Pavlov et al. (2002), Molecular and Cellular Neuroscience; Vol. 20, pp. 330-342. Tg mice are viable and no anatomical abnormalities are detected.  
Colony maintenance Carrier x Carrier  
Health Report
Gene Details
Promoter human PDGF-beta promoter  
 1 Symbol Ptn  
Symbol name pleiotrophin (rat)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
References   
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use the BIOLOGICAL RESOURCE, a citation of the following literature designated by the DEPOSITOR is requested. Mol. Cell Neurosci., 2002 20(2):330-242. A recipient shall acquire a prior consent from the DEPOSITOR for the use of the mice.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Rauvala, Heikki (University of Helsinki)  Rauvala, Heikki 
Strain Status /
Availability
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