Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC04791  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129P2-Dapk1<tm1Yuk>  
Former Common name B6;129P2-Dapk1, DAPK KO  
H-2 Haplotype No Data  
ES cell line E14 [129P2/OlaHsd]  
Background strain C57BL/6JJcl  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Dr. Kazunori Yukawa, Wakayama Medical University and Dr. Sizuo Akira, Research Institute for Microbial Disease, Osaka University in 2004. C57BL/6J background.  
Strain description Dapk1 gene knockout mice. Exon encoding amino acids 22-95 of Dapk1 gene was replaced with a neomycin resistant cassette.  
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Homozygous mutant mice are viable and fertile, but females of homozygote show slightly lower reproductive performance.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Dapk1  
Symbol name death associated protein kinase 1  
Chromosome 13  
Common name No Data  
Symbol description No Data  
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 13  
Common name neo; neomycin;  
Symbol description No Data  
References J Am Soc Nephrol. 2004 Jul;15(7):1826-34.

  
Deletion of the kinase domain in death-associated protein kinase attenuates tubular cell apoptosis in renal ischemia-reperfusion injury.
Deletion of the kinase domain in death-associated protein kinase attenuates tubular cell apoptosis in renal ischemia-reperfusion injury.
Deletion of the kinase domain in death-associated protein kinase attenuates tubular cell apoptosis in renal ischemia-reperfusion injury.
Research applications Cell Biology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Int. J. Mol. Med., 13, 515-520 (2004).  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Wakayama Medical University   
Strain Status /
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