Strain Data Sheet

RBRC04803

Strain Information

Image
BRC No.RBRC04803
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Bmper<tm2Ysas>/Rbrc
Former Common nameCv2(nlacZ) (Acc.No.CDB0451K)
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain developmentDeveloped by Dr. Yoshiki Sasai, Center for Developmental Biology, RIKEN.
Strain descriptionThis transgene contains beta-galactosidase with a nuclear localization signal. The first methionine of Cv2 was replaced in-flame with that of lacZ. Cv2 (Bmper : BMP-binding endothelial regulator) is essential for multiple organogenetic processes that involve Bmp signals. Cv2 homozygous mutant mice show effects in the vertebral column and eyes.
Colony maintenanceHeterozygote x Wild-type [C57BL/6] Homozygous mutant mice are neonatal lethal.
ReferencesDevelopment, 133, 4463-4473 (2006). 17035289

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
BmperBMP-binding endothelial regulator9Bmper<tm2Ysas>targeted mutation 2, Yoshiki Sasai

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
lacZbeta-galactosidase (E. coli)9

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP9loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)9neo; neomycin;

Ordering Information

Donor DNALacZ (大腸菌), polyA (SV40), PGK promoter (mouse) Neo (大腸菌), loxP (P1ファージ)
Research application
Specific Term and Conditions(1) The RECIPIENT shall obtain a prior agreement from Dr. Makoto Ikeya (mikeya@cira.kyoto-u.ac.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. CDB0451K, and Web Site (https://large.riken.jp/distribution/mutant-list.html) and the BIOLOGICAL RESOURCE is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (Development, 133, 4463-4473 (2006).) (4) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published.
DepositorRIKEN CDB (RIKEN CDB)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data