Strain Data Sheet
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Data update: Jul 19, 2019
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RBRC No. RBRC04803  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.Cg-Bmper<tm2Ysas>/Rbrc  
Former Common name Cv2(nlacZ) (Acc.No.CDB0451K)  
H-2 Haplotype No Data  
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Dr. Yoshiki Sasai, Center for Developmental Biology, RIKEN.  
Strain description This transgene contains beta-galactosidase with a nuclear localization signal. The first methionine of Cv2 was replaced in-flame with that of lacZ. Cv2 (Bmper : BMP-binding endothelial regulator) is essential for multiple organogenetic processes that involve Bmp signals. Cv2 homozygous mutant mice show effects in the vertebral column and eyes.  
Colony maintenance Heterozygote x Wild-type [C57BL/6] Homozygous mutant mice are neonatal lethal.  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Bmper  
Symbol name BMP-binding endothelial regulator  
Chromosome 9  
Common name No Data  
Symbol description No Data  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome No Data  
Common name neo; neomycin;  
Symbol description No Data  
 3 Symbol lacZ  
Symbol name beta-galactosidase (E. coli)  
Chromosome No Data  
Common name No Data  
Symbol description No Data  
 4 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome No Data  
Common name No Data  
Symbol description No Data  
References Development. 2006 Nov;133(22):4463-73. Epub 2006 Oct 11.  
Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis.
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
1) The RECIPIENT shall obtain a prior agreement from Dr. Yoshiki Sasai (yoshikisasai@cdb.riken.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. CDB0451K, and Web Site (http:www.cdb.riken.jp/arg/mutant%20mice%20list.html) and the BIOLOGICAL RESOURCE is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (Development, 133, 4463-4473 (2006).) (4) Please inform the DEPOSITOR (mutant@cdb.riken.jp) about the paper when published.  
Additional information
 1 No Data  
Depositor RIKEN, CDB (RIKEN Center for Developmental Biology)  RIKEN, CDB 
Strain Status /
Availability
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