Strain Data Sheet
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Data update: Jul 19, 2019
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RBRC No. RBRC04834  
Type Chemically-induced Mutation  
Species Mus musculus  
Strain name C57BL/6J-Slc7a11<m1Mtka>  
Former Common name xCT mutant  
H-2 Haplotype No Data  
Background strain C57BL/6JJcl  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Masato Tanaka, RIKEN Research Center for Allergy and Immunologuy in 2005. Generated by RIKEN ENU mutagenesis project.  
Strain description Slc7a11 mutant mice generated by ENU mutagenesis. A transverstion of G to T in exon 10 was caused and results in a premature termination at position 383 glycine. Homozygous mutant mice exhibit decreased survival of LPS-induced macropgages and increase chemically-induced tumors.  
Colony maintenance Heterozygote X Wild-type [C57BL/6JJcl] Homozygous mutant mice exhibit decreased survival of LPS-induced macropgages and increase chemically-induced tumors.  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Slc7a11  
Symbol name solute carrier family 7 (cationic amino acid transporter, y+ system), member 11  
Chromosome 3  
Common name xCTmu  
Symbol description No Data  
References   
Research applications Cancer Research,
Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Proc. Matl. Acad. Sci., USA, 107, 6436-6441(2010).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
A RECIPIENT shall obtain a prior written approval from the DEPOSITOR using approval form.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Tanaka, Masato (RIKEN Research Center For Allergy and Immunology)  Tanaka, Masato 
Strain Status /
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