Strain Information | |
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Image | |
BRC No. | RBRC04937 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6;129S4-Atrx<tm1Enl> |
Former Common name | B6-Atrx KO (ATRX<deltaE2>) |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Hideyuki Beppu and En Li, Massachusetts General Hospital, Harvard Medical School. |
Strain description | |
Colony maintenance | Heterozygote (female), Hemizygote (male) x Wild-type [C57BL/6JJmsSlc] |
References | J. Neurosci., 31, 346-358 (2011). 21209221 Hippocampus, 21, 678-687 (2011). 20865721 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)XAtrx<tm1Enl>targeted mutation 1, En Li Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter IRESinternal ribosomal entry site (EMCV)Xinternal ribosomal entry site from EMCV Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter lacZbeta-galactosidase (E. coli)X Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)Xneo; neomycin; |
Ordering Information | |
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Donor DNA | Mouse En-2 splicing acceptor, Encephalomyocarditis virus Internal ribosome-entry site, E. coli LacZ, E. coli Neomycin resistance gene, SV40 PolyA signal |
Research application | Mouse Models for Human Disease Neurobiology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature designated by the DEPOSITOR is requested. Hippocampus. 2011 21(6):678-87. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and Massachusetts General Hospital (Boston, USA) and must obtain a prior written consent from the DEPOSITOR and Massachusetts Genearal Hospital. |
Depositor | Hideyuki Beppu (University of Toyama) |
Strain Status | Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Shioda N, Yabuki Y, Yamaguchi K, Onozato M, Li Y, Kurosawa K, Tanabe H, Okamoto N, Era T, Sugiyama H, Wada T, Fukunaga K. Targeting G-quadruplex DNA as cognitive function therapy for ATR-X syndrome. Nat Med 24(6) 802-813(2018) 29785027 |