Strain Data Sheet
Data update: Jul 19, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC05235  
Type TransgeneCartagena  
Species Mus musculus  
Strain name C57BL/6-Tg(TH-ALK*F1174L)9Homy  
Former Common name B6-Th-ALK/F1174L Tg#9L  
H-2 Haplotype No Data  
Background strain No Data  
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Hiroaki Honda, Research Institute for Radiation Biology and Medicine and Junko Takita, The University of Tokyo Hospital. A F1174L mutant hALK gene under the TH promoter was injected into the pronuclei of C57BL/6N fertilized eggs.  
Strain description Human ALK (anaplastic lymphoma kinase) gene having F1174L mutation transgenic mice. F1174L mutation was identified in a patient with an inflammatory myofibroblastic tumor harboring a RANBP2-ALK translocation.  
Health Report
Gene Details
Promoter human tyrosine hydroxylase promoter  
 1 Symbol ALK  
Symbol name human ALK cDNA (F1174L mutant)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
References Nature. 2008 Oct 16;455(7215):971-4.  
Oncogenic mutations of ALK kinase in neuroblastoma.
Research applications Cancer Research,
Mouse Models for Human Disease  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.  
Additional information
 1 No Data  
Depositor Honda, Hiroaki (Tokyo Women's Medical University)  Honda, Hiroaki 
Strain Status /
(Expected delivery)

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