Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
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RBRC No. RBRC05236  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129-Col19a1<tm1Rmz>  
Former Common name B6-Col19a1 KO  
H-2 Haplotype No Data  
ES cell line R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Hideaki Sumiyoshi (Oita Medical University), Francesco Ramirez (Weill College of Medical of Cornell University) and Hidekatsu Yoshioka (Oita Medical University).  
Strain description Coll9a1 knockout mice. IRES-lacZ and PGK-neo cassette replaced exon 4 of Col19a1. Homozygous mutant mice show eating disorder by impaired sphincter relaxation in the lower esophagus, and more than 90% (in 129), 30-50% (in C57BL/6) of the mice die within 3 weeks after birth. Esophagus achalasia is also observed with aging.  
Colony maintenance Heterozygote x Wild-type  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Col19a1  
Symbol name collagen, type XIX, alpha 1  
Chromosome 1  
Common name No Data  
Symbol description No Data  
References J Cell Biol 2004 Aug 16;166(4):591-600. Epub 2004 Aug 9.  
Esophageal muscle physiology and morphogenesis require assembly of a collagen XIX-rich basement membrane zone.
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.  
Additional information
 1 No Data  
Depositor Yoshioka, Hidekatsu (Oita university)  Yoshioka, Hidekatsu 
Strain Status /
Availability
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