Strain Information | |
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Image | |
BRC No. | RBRC05273 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.Cg-Prickle1<tm1Nue>/Rbrc |
Former Common name | mpk1 (Acc. No. CDB0431K) |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | |
Appearance | |
Strain development | Developed by Naoto Ueno, National Institute for Basic Biology. |
Strain description | Prickle1, prickle homolog 1 (Drosophila) Knockout mice (mpk1(lacZ)). Homozygous mutant mice die between E7.5 and E8.5. Heterozygous mutant mice show decreased seizure threshold compared with wild-type. |
Colony maintenance | Heterozygote x Wild-type [C57BL/6N] |
References | Proc. Natl. Acad. Sci. USA, 106, 14426-14431 (2009). 19706528 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Frtyeast FRT (flippase recombination target) site15Frt Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter lacZbeta-galactosidase (E. coli)15 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter lox71mutant lox sequence15lox71 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP15loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)15neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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Donor DNA | LacZ, Neo : 大腸菌由来 / loxP, lox71 : P1ファージ由来 / frt : 酵母由来 / rabbit beta-globin 3’ end : ウサギ由来, Mouse PGK promoter |
Research application | |
Specific Term and Conditions | (1) The RECIPIENT shall obtain a prior agreement from the DEVELOPER (Dr. Naoto Ueno, National Institute for Basic Biology, E-mail: nueno@nibb.ac.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Acc.No. CDB0431K and Web. Site (https://large.riken.jp/distribution/mutant-list.html) is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (Proc Natl Acad Sci U S A. 2009 106(34):14426-31.) (4) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published. |
Depositor | RIKEN CDB (RIKEN CDB) |
Strain Status | Frozen embryos |
Strain Availability | Recovery and QC required prior to distribution |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |