Strain Data Sheet
RBRC05281
Strain Information | |
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| Image | |
| BRC No. | RBRC05281 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | B6.Cg-Ltbr<tm1Mmat>/Rbrc |
| Former Common name | LtbR (Acc. No. CDB0531K) |
| H-2 Haplotype | |
| ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
| Background strain | |
| Appearance | |
| Strain development | Developed by Mitsuru Matsumoto, Institute for Enzyme Research, The University of Tokushima. |
| Strain description | Lymphotoxin B receptor knockout mice. Homozygous mutant miceexhibit accumulation of lymphoid cell aggregates (B220+, CD4+, and CD8+ lymphocytes) in the liver and lung. |
| Colony maintenance | Heterozygote x Wild-type [C57BL/6N] |
| References | J. Immunol., 86, 5047-5057 (2011). 21441458 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |
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| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Frtyeast FRT (flippase recombination target) site6Frt Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter lacZbeta-galactosidase (E. coli)6 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter lox71mutant lox sequence6lox71 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP6loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)6neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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| Donor DNA | phage P1 lox71, E. coli lacZ, polyA, yeast FRT (flipase recombination target) sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse PGK3’end, phage P1 loxP site, rabbit beta-globin 3’end, mouse LtbR genomic DNA |
| Research application | |
| Specific Term and Conditions | (1) The RECIPIENT shall obtain a prior agreement from the DEVELOPER (Dr. Mitsuru Matsumoto, The University of Tokushima, E-mail: mitsuru@ier.tokushima-u.ac.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Acc.No. CDB0531K and Web. Site (https://large.riken.jp/distribution/mutant-list.html) is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (J Immunol. 2011 186(9):5047-57.) (4) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published. |
| Depositor | RIKEN CDB (RIKEN CDB) |
| Strain Status |  Frozen sperm |
| Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Mouse of the Month Oct 2013 |
BRC mice in Publications |
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