Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
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RBRC No. RBRC05290  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129P2-Dscam<tm1.1Kzy>/A151Kzy  
Former Common name B6-Dscam KO#A151  
H-2 Haplotype No Data  
ES cell line E14 [129P2/OlaHsd]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Exon 1 was removed by crossing with CAG-cre (B6 background). The mice were backcrossed to C57BL/6 over 21 times.  
Strain description Dscam knockout mice. Dscam, Down syndrome cell adhesion molecule is a gene of neural Ig superfamily mediates cell adhesion and axon outgrowth. Homozygous mutant mice of C57BL/6 genetic background die within 24 hours after birth due to central respiratory defects. In BALB/c mixed background, Homozygous mutant mice are viable and survive to adulthood.  
Colony maintenance Heterozygote x Wild-type [C57BL/6NCrSlc]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Dscam  
Symbol name Down syndrome cell adhesion molecule  
Chromosome 16  
Common name No Data  
Symbol description No Data  
 2 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 16  
Common name No Data  
Symbol description No Data  
References   
Research applications Cre/loxP system,
Mouse Models for Human Disease,
Neurobiology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Amano et al., J. Neurosci., 29(9):2984-2996. 2009
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.  
Additional information
 1 Mouse of the Month Jan 2012  
 2 Genotyping protocol <PCR>  
Depositor Yamakawa, Kazuhiro (RIKEN)  Yamakawa, Kazuhiro 
Strain Status /
Availability
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