Strain Information | |
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Image | |
BRC No. | RBRC05430 |
Type | Congenic |
Species | Mus musculus |
Strain name | BXSB.B6-Fcgr2b<C57BL/6>/Hros |
Former Common name | |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Sachiko Hirose, Department of Internal Medicine, Juntendo University School of Medicine in 2006. A neomycin selection cassette was transferred into BL/6-III ES cells to delete and replace exon 2 of Fcer1g gene. A IgG Fc gamma RIIB (Fcgr2b) promoter region variant derived from C57BL/6 was backcrossed to BXSB strain over 20 generations. |
Strain description | BXSB congenic strain having a IgG Fc gamma RIIB (Fcgr2b) promoter region variant derived from C57BL/6. Autoimmune disease features of male were markedly suppressed in homozygous mutant mice. |
Colony maintenance | Homozygote x Homozygote [or Crossing to BXSB/MpJJmsSlc (female)] |
References | J. Immunol., 177, 1646-1654 (2006). 16849473 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter |
Ordering Information | |
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Donor DNA | |
Research application | Immunology and Inflammation Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 177, 1646-1654 (2006). |
Depositor | Sachiko Hirose (Juntendo University) |
Strain Status | Frozen sperm |
Strain Availability | Recovery and QC required prior to distribution |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |