Strain Data Sheet

RBRC05430

Strain Information

Image
BRC No.RBRC05430
TypeCongenic
SpeciesMus musculus
Strain nameBXSB.B6-Fcgr2b<C57BL/6>/Hros
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Sachiko Hirose, Department of Internal Medicine, Juntendo University School of Medicine in 2006. A neomycin selection cassette was transferred into BL/6-III ES cells to delete and replace exon 2 of Fcer1g gene. A IgG Fc gamma RIIB (Fcgr2b) promoter region variant derived from C57BL/6 was backcrossed to BXSB strain over 20 generations.
Strain descriptionBXSB congenic strain having a IgG Fc gamma RIIB (Fcgr2b) promoter region variant derived from C57BL/6. Autoimmune disease features of male were markedly suppressed in homozygous mutant mice.
Colony maintenanceHomozygote x Homozygote [or Crossing to BXSB/MpJJmsSlc (female)]
ReferencesJ. Immunol., 177, 1646-1654 (2006). 16849473

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Fcgr2bFc receptor, IgG, low affinity IIb1Fcgr2b < >

Ordering Information

Donor DNA
Research applicationImmunology and Inflammation Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 177, 1646-1654 (2006).
DepositorSachiko Hirose (Juntendo University)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

BRC mice in Publications

No Data