Strain Data Sheet
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC05473  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129S6-Mad2l2<tm1Myo>  
Former Common name Rev7 KO, B6-Mad2l2 KO  
H-2 Haplotype No Data  
ES cell line CSL3[129S6/SvEvTac]  
Background strain No Data  
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Yoshiki Murakumo, Nagoya University Graduate School of Medicine in 2009. The mutant mice were backcrossed to C57BL/6.  
Strain description Rev7 (Mad2l2) knockout mice. Homozygous mutant mice lack germ cells due to apoptosis of primordial germ cell in the middle phase of the embryonic development.  
Colony maintenance Heterozygote x Wild-type [C57BL/6JJmsSlc]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Mad2l2  
Symbol name MAD2 mitotic arrest deficient-like 2 (yeast)  
Chromosome 4  
Common name Rev7  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 4  
Common name No Data  
Symbol description No Data  

Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Biol. Chem., 288(15):10459-10471 (2013).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
For profit use of the BIOLOGICAL RESSOURCE, the RECIPIENT must contact with the Intellectual Property Office, Nagoya University to obtain a prior written consent.
The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Murakumo, Yoshiki (Nagoya University Graduate School of Medicine)  Murakumo, Yoshiki 
Strain Status /
(Expected delivery)

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