Strain Data Sheet
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC05517  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6;129S4-Xbp1<tm1Tiw>  
Former Common name XBP1 KO, B6-Xbp1 KO  
H-2 Haplotype No Data  
ES cell line RF8 [129S4/SvJae]  
Background strain No Data  
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Takao Iwawaki, Advanced Science Institute, RIKEN in 2005. RF8 (129S4 derived) ES cells were used. The mutant mice were backcrossed to C57BL/6J for at least 5 times.  
Strain description Xbp1 gene knockout mice. Exons 2-4 were replaced with a floxed neo cassette. Homozygous mutant mice begin to die around E12.5.  
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Xbp1  
Symbol name X-box binding protein 1  
Chromosome 11  
Common name No Data  
Symbol description No Data  
 2 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 11  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 3 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 11  
Common name neo; neomycin;  
Symbol description No Data  
Research applications Cre/loxP system  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Proc. Natl. Acad. Sci. USA, 106, 16657-16662 (2009).  
Additional information
 1 Lab HP  
 2 Genotyping protocol <PCR>  
Depositor Iwawaki, Takao (Medical research institute,kanazawa medical university)  Iwawaki, Takao 
Strain Status /
(Expected delivery)

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