Strain Information | |
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Image | |
BRC No. | RBRC05537 |
Type | Transgene |
Species | Mus musculus |
Strain name | C3H.C3B6-Tg(HIV NL4-3dPol)1607Yiw |
Former Common name | C3-HIV/NL43dPol Tg#1607 |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo in 1992. Transgene was injected into the pronuclei of B6C3F1 fertilized eggs. C3H background. |
Strain description | Transgenic mice having a NL4-3 region of human immunodeficiency virus (HIV). C3H background. HIV gRNA (non-infectious) is produced in several organs. Tg mice show decreased body weight and cataract with aging. |
Colony maintenance | Carrier x Noncarrier [or Crossing to C3H/HeNSlc] |
References | AIDS, 6, 1069-1075 (1992). 1466838 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter HIVhuman immunodeficiency virusUNHIV |
Ordering Information | |
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Donor DNA | 11.5 kb BglI-NcoI fragment derived from pNL4-3-2 (The fragment consists of the entire defective HIV proviral genome (9.4 kb: KpnI fragment deletion, nucleotide number 3826-4154)), the cellular franking sequence (2.0 kb), and the bacterial vector sequence (57 bp).) |
Research application | Immunology and Inflammation Research |
Specific Term and Conditions | Please obtain the written consent from Professor Yoichiro Iwakura(iwakura@rs.tus.ac.jp; Research Institute for Biological Sciences, Tokyo University of Science)for the use. |
Depositor | Yoichiro Iwakura (The University of Tokyo) |
Strain Status | Frozen embryos |
Strain Availability | Recovery and QC required prior to distribution |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |