Strain Data Sheet
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC05540  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129-Brd1<tm1Hko>  
Former Common name Brd1 KO, B6-Brd1 KO  
H-2 Haplotype No Data  
Background strain No Data  
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Atsushi Iwama, Graduate School of Medicine, Chiba University and Akihiko Koseki, RIKEN Research Center for Allergy and Immunology in 2005. The mutant mice were backcrossed to C57BL/6N.  
Strain description Brd1 gene knockout mice. Exon 2 of Brd1 gene was replaced with a floxed neo cassette. Homozygous mutant mice show abnormal embryonic development including erythropoiesis (anemia), growth retardation, open neural tube and abnormal lens morphology, and die between E12.5 and E14.5.  
Colony maintenance Heterozygote x Wild-type [C57BL/6NCrSlc]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Brd1  
Symbol name bromodomain containing 1  
Chromosome 15  
Common name No Data  
Symbol description No Data  
 2 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 15  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 3 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 15  
Common name neo; neomycin;  
Symbol description No Data  
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Blood, 118, 2443-2453 (2011).  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Iwama, Atsushi (Graduate School of Medical and Pharmaceutical Sciences, Chiba University)  Iwama, Atsushi 
Strain Status /
(Expected delivery)

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