Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
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RBRC No. RBRC05552  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name 129S6.129S(Cg)-Grm6<tm1Nak>  
Former Common name 129-mGluR6 KO, 129-Grm6 KO  
H-2 Haplotype No Data  
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]  
Background strain 129S6/SvEvTac  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Shigetada Nakanishi and Takahisa Furukawa, Osaka Bioscience Institute in 2012. The mutant mice were generated by backcrossing to 129S6/SvEvTac from B6-Grm6-lacZ Tg/Grm6 KO mice (RBRC01353).  
Strain description mGluR6 (Grm6) knockout mice. 126 background. 1.2 kb sequence encoding part of the transmembrane region of Grm6 gene was replaced with a neomycin resistance cassette.  
Colony maintenance Heterozygote x Wild-type [or Crossing to 129S6/SvEvTac]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Grm6  
Symbol name glutamate receptor, metabotropic 6; targeted mutation 1, Shigetada Nakanishi  
Chromosome 11  
Common name No Data  
Symbol description No Data  
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 11  
Common name neo; neomycin;  
Symbol description No Data  
References Cell. 1995 Mar 10;80(5):757-65.
J Neurosci. 1999 Apr 1;19(7):2568-79.  
Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene.
Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene.
Research applications Neurobiology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Cell, 80, 757-765 (1995). J. Neurosci., 19, 2568-2579 (1999).
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must contract an MTA with the DEPOSITOR (Osaka University).  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Furukawa, Takahisa (Osaka Bioscience Institute)  Furukawa, Takahisa 
Strain Status /
Availability
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