Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Aug 20, 2019
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RBRC No. RBRC05653  
Type TransgeneCartagena  
Species Mus musculus  
Strain name B6.Cg-Tg(alpha-MHC/miR143/145)19  
Former Common name B6-aMHC/miR143/145 Tg#19  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Takashi Iwamoto, College of Life and Health Sciences, Chubu University in 2010. The transgene was injected into the (C57BL/6 x BALB/c)F2 fertilized eggs. The mice were crossed to C57BL/6J over 5 generations.  
Strain description Transgenic mice expressing miR-143 and miR-145 in cardiomyocytes. Their hearts generally show low %FS after 2 months old and become enlarged.  
Colony maintenance Carrier x Noncarrier [C57BL/6J(Crlj)]
Tg mice show a high incidence of sudden death after 2-3 months old.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol miR145  
Symbol name pri-miR-145 (human)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
Promoter rat alpha-myosine heavy chain promoter  
 2 Symbol miR143  
Symbol name pri-miR-143 (human)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
References Biochem Biophys Res Commun. 2008 Aug 8;372(4):856-61. Epub 2008 Jun 3.
  
Establishment of cells to monitor Microprocessor through fusion genes of microRNA and GFP.
Establishment of cells to monitor Microprocessor through fusion genes of microRNA and GFP.
Research applications Cardiovascular Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature designated by the DEPOSITOR is requested (will be announced). Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval form the DEPOSITOR using the Approval Form. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from use of the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
Depositor Iwamoto, Takashi (Chubu University)  Iwamoto, Takashi 
Strain Status /
Availability
(Expected delivery)

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