Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
Figure
  Order
RBRC No. RBRC05663  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.Cg-Bcl6<tm1.1Mtto>  
Former Common name Bcl6-Flox mouse, B6-Bcl6 floxed  
H-2 Haplotype No Data  
ES cell line Bruce 4 [B6.Cg-Thy1]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Toshitada Takemori, RIKEN Center for Allergy and Immunology in 2008. Bruce 4 ES cells derived from B6.Cg-Thy1.1 were used. A frt flanked neo cassette was removed by crossing with CAG-FLPe mice#23 (B6).  
Strain description Bcl6 gene floxed mice. Exons 7 to 9 were flanked by loxP sites.  
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6JJcl]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Bcl6  
Symbol name B cell leukemia/lymphoma 6  
Chromosome 16  
Common name No Data  
Symbol description No Data  
 2 Symbol Frt  
Symbol name yeast FRT (flippase recombination target) site  
Chromosome 16  
Common name No Data  
Symbol description No Data  
 3 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 16  
Common name No Data  
Symbol description No Data  
References   
Research applications Cre/loxP system,
FLP/frt system,
Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature designated by the DEPOSITOR is requested. Distinct cellular pathways select germ-line encoded and somatically mutated antibodies into immunological memory. J. Exp. Med., 209, 2079-2097 (2012). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.  
Additional information
 1 Mouse of the Month Jun 2013  
 2 Genotyping protocol <PCR>  
Depositor Takemori, Toshitada (RIKEN Research Center For Allergy and Immunology)  Takemori, Toshitada 
Strain Status /
Availability
(Expected delivery)

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